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KMID : 0545120150250081265
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Journal of Microbiology and Biotechnology
2015 Volume.25 No. 8 p.1265 ~ p.1274
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Metabolomics-Based Chemotaxonomic Classification of Streptomyces spp. and Its Correlation with Antibacterial Activity
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Lee Mee-Youn
Kim Hyang-Yeon
Lee Sa-Rah
Kim Jeong-Gu
Suh Joo-Won
Lee Choong-Hwan
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Abstract
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Secondary metabolite-based chemotaxonomic classification of Streptomyces (8 species, 14 strains) was performed using ultraperformance liquid chromatography-quadrupole-time-offlight- mass spectrometry with multivariate statistical analysis. Most strains were generally well separated by grouping under each species. In particular, S. rimosus was discriminated from t he r emaining s ev en s pecies ( S. coelicolor, S. griseus, S. indigoferus, S. peucetius, S. rubrolavendulae, S. scabiei, and S. virginiae) in partial least squares discriminant analysis, and oxytetracycline and rimocidin were identified as S. rimosus-specific metabolites. S. rimosus also showed high antibacterial activity against Xanthomonas oryzae pv. oryzae, the pathogen responsible for rice bacterial blight. This study demonstrated that metabolite-based chemotaxonomic classification is an effective tool for distinguishing Streptomyces spp. and for determining their species-specific metabolites.
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KEYWORD
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Streptomyces, Chemotaxonomy, Antibacterial activity
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